The Church of San Francesco hosts the testimony of the oldest Eucharistic miracle of the Catholic world. Around the year 700 a Basilian monk doubted the real presence of Christ in the Eucharist: during the mass the consecrated host and wine became flesh and blood. The two relics, 5 drops of coagulated blood and a thin membrane of flesh are respectively preserved in a silver monstrance and in a crystal ampoule.Histological examinations,have shown that it is human blood and heart tissue with the same blood group (AB).The sanctuary is visited every year by thousands of pilgrims from all over the world. The Shrine of Manoppello is recognised as the true Face of Jesus Christ. From 1646 the Holy Face is exposed to the veneration of the people.It is a soft veil, the warp and the weft are intertwined in the form of a normal weaving and the Face of the Shroud of Turin and that of Manoppello fit perfectly, because both fabrics had been laid on the body of Jesus.